Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.
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ABSTRACT: Objective
To study the association between wheezy symptoms in young children and the presence of bacteria in the airways.Design
Birth cohort study.Setting
Clinical research unit in Copenhagen.Participants
Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic.Main outcome measure
Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms.Results
984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P<0.001) and virus infection (2.8, 1.7 to 4.4; P<0.001). The associations of bacteria and viruses were independent of each other.Conclusion
Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.
SUBMITTER: Bisgaard H
PROVIDER: S-EPMC2950260 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.
Bisgaard Hans H Hermansen Mette Northman MN Bønnelykke Klaus K Stokholm Jakob J Baty Florent F Skytt Nanna Lassen NL Aniscenko Julia J Kebadze Tatiana T Johnston Sebastian L SL
BMJ (Clinical research ed.) 20101004
<h4>Objective</h4>To study the association between wheezy symptoms in young children and the presence of bacteria in the airways.<h4>Design</h4>Birth cohort study.<h4>Setting</h4>Clinical research unit in Copenhagen.<h4>Participants</h4>Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic.<h4>Main outcome measure</h4>Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits with ...[more]
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