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Genetic variation in microRNA networks: the implications for cancer research.

ABSTRACT: Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.

SUBMITTER: Ryan BM

PROVIDER: S-EPMC2950312 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Genetic variation in microRNA networks: the implications for cancer research.

Ryan Bríd M BM Robles Ana I AI Harris Curtis C CC

Nature reviews. Cancer 20100601 6

Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which str ...[more]

PMID: 20495573

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