Ontology highlight
ABSTRACT:
SUBMITTER: Martins Vde P
PROVIDER: S-EPMC2950344 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Martins Vicente de Paulo Vde P Galizzi Melina M Salto Maria Laura ML Docampo Roberto R Moreno Silvia N J SN
Infection and immunity 20100719 10
Phosphoinositide phospholipase C (PI-PLC) plays an essential role in cell signaling. A unique Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N terminus and localizes to the outer surface of the plasma membrane of amastigotes. We show here that TcPI-PLC is developmentally regulated in amastigotes and shows two peaks of surface expression during the developmental cycle of T. cruzi, the first immediately after differentiation of trypomastigotes into amastigotes and the second before d ...[more]