Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection.
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ABSTRACT:
SUBMITTER: Molloy M
PROVIDER: S-EPMC2950560 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection.
Molloy Michael M Zhang Weijun W Usherwood Edward E
Journal of virology 20100804 20
Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8(+) T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8(+) T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expan ...[more]
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