Ontology highlight
ABSTRACT:
SUBMITTER: Coombs KM
PROVIDER: S-EPMC2950599 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Coombs Kevin M KM Berard Alicia A Xu Wanhong W Krokhin Oleg O Meng Xiaobo X Cortens John P JP Kobasa Darwyn D Wilkins John J Brown Earl G EG
Journal of virology 20100811 20
Because they are obligate intracellular parasites, all viruses are exclusively and intimately dependent upon host cells for replication. Viruses, in turn, induce profound changes within cells, including apoptosis, morphological changes, and activation of signaling pathways. Many of these alterations have been analyzed by gene arrays, which measure the cellular "transcriptome." Until recently, it has not been possible to extend comparable types of studies to globally examine all the host cellular ...[more]