Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles.
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SUBMITTER: Kim JA
PROVIDER: S-EPMC2950751 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
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Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles.
Kim Jung A JA Roy Roland R RR Kim Soo J SJ Zhong Hui H Haddad Fadia F Baldwin Kenneth M KM Edgerton V Reggie VR
Muscle & nerve 20100901 3
The extent and mechanisms by which neural input regulates skeletal muscle mass remain largely unknown. Adult spinal cord isolated (SI) rats were implanted unilaterally with a microstimulator, whereas the contralateral limb served as SI control (SI-C). A 100-HZ, 1-s stimulus was delivered every 30 s for 5 min, followed by a 5-min rest. This was repeated six times consecutively (SI-Stim1) or with a 9-h interval after the third bout (SI-Stim2) for 30 days (1 min of daily activity). SI-Stim1 and SI- ...[more]
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