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A small molecule inhibitor of alpha4 integrin-dependent cell migration.

ABSTRACT: A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.

SUBMITTER: Lee J 

PROVIDER: S-EPMC2951142 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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A small molecule inhibitor of alpha4 integrin-dependent cell migration.

Lee Jongkook J   Hong Jiyong J   Nam Tae-Gyu TG   Peters Eric C EC   Orth Anthony P AP   Geierstanger Bernhard H BH   Goldfinger Lawrence E LE   Ginsberg Mark H MH   Cho Charles Y CY   Schultz Peter G PG  

Bioorganic & medicinal chemistry 20080226 3

A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. ...[more]

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