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GATA switches as developmental drivers.

ABSTRACT: Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

SUBMITTER: Bresnick EH

PROVIDER: S-EPMC2951181 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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GATA switches as developmental drivers.

Bresnick Emery H EH Lee Hsiang-Ying HY Fujiwara Tohru T Johnson Kirby D KD Keles Sunduz S

The Journal of biological chemistry 20100729 41

Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 tra ...[more]

PMID: 20670937

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