Ontology highlight
ABSTRACT:
SUBMITTER: O'Sullivan RJ
PROVIDER: S-EPMC2951278 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
O'Sullivan Roderick J RJ Kubicek Stefan S Schreiber Stuart L SL Karlseder Jan J
Nature structural & molecular biology 20101003 10
During replicative aging of primary cells morphological transformations occur, the expression pattern is altered and chromatin changes globally. Here we show that chronic damage signals, probably caused by telomere processing, affect expression of histones and lead to their depletion. We investigated the abundance and cell cycle expression of histones and histone chaperones and found defects in histone biosynthesis during replicative aging. Simultaneously, epigenetic marks were redistributed acr ...[more]