Ontology highlight
ABSTRACT:
SUBMITTER: Qi Y
PROVIDER: S-EPMC2951314 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nature 20091201 7274
How living systems detect the presence of genotoxic damage embedded in a million-fold excess of undamaged DNA is an unresolved question in biology. Here we have captured and structurally elucidated a base-excision DNA repair enzyme, MutM, at the stage of initial encounter with a damaged nucleobase, 8-oxoguanine (oxoG), nested within a DNA duplex. Three structures of intrahelical oxoG-encounter complexes are compared with sequence-matched structures containing a normal G base in place of an oxoG ...[more]