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ABSTRACT:
SUBMITTER: Hothorn M
PROVIDER: S-EPMC2951410 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hothorn Michael M Van den Ende Wim W Lammens Willem W Rybin Vladimir V Scheffzek Klaus K
Proceedings of the National Academy of Sciences of the United States of America 20100921 40
Invertases are highly regulated enzymes with essential functions in carbohydrate partitioning, sugar signaling, and plant development. Here we present the 2.6 Å crystal structure of Arabidopsis cell-wall invertase 1 (INV1) in complex with a protein inhibitor (CIF, or cell-wall inhibitor of β-fructosidase) from tobacco. The structure identifies a small amino acid motif in CIF that directly targets the invertase active site. The activity of INV1 and its interaction with CIF are strictly pH-depende ...[more]