Ontology highlight
ABSTRACT:
SUBMITTER: Tham WH
PROVIDER: S-EPMC2951459 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Tham Wai-Hong WH Wilson Danny W DW Lopaticki Sash S Schmidt Christoph Q CQ Tetteh-Quarcoo Patience B PB Barlow Paul N PN Richard Dave D Corbin Jason E JE Beeson James G JG Cowman Alan F AF
Proceedings of the National Academy of Sciences of the United States of America 20100920 40
Plasmodium falciparum is responsible for the most severe form of malaria disease in humans, causing more than 1 million deaths each year. As an obligate intracellular parasite, P. falciparum's ability to invade erythrocytes is essential for its survival within the human host. P. falciparum invades erythrocytes using multiple host receptor-parasite ligand interactions known as invasion pathways. Here we show that CR1 is the host erythrocyte receptor for PfRh4, a major P. falciparum ligand essenti ...[more]