Ontology highlight
ABSTRACT:
SUBMITTER: Douat-Casassus C
PROVIDER: S-EPMC2951488 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Douat-Casassus Céline C Borbulevych Oleg O Tarbe Marion M Gervois Nadine N Jotereau Francine F Baker Brian M BM Quideau Stéphane S
Journal of medicinal chemistry 20101001 19
There is growing interest in using tumor associated antigens presented by class I major histocompatibility complex (MHC-I) proteins as cancer vaccines. As native peptides are poorly stable in biological fluids, researchers have sought to engineer synthetic peptidomimetics with greater biostability. Here, we demonstrate that antigenic peptidomimetics of the Melan-A/MART-1(26(27L)-35) melanoma antigen adopt strikingly different conformations when bound to MHC-I, highlighting the degeneracy of T ce ...[more]