Ontology highlight
ABSTRACT:
SUBMITTER: Buzzo CL
PROVIDER: S-EPMC2952210 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Buzzo Carina L CL Campopiano Julia C JC Massis Liliana M LM Lage Silvia L SL Cassado Alexandra A AA Leme-Souza Rafael R Cunha Larissa D LD Russo Momtchilo M Zamboni Dario S DS Amarante-Mendes Gustavo P GP Bortoluci Karina R KR
The Journal of biological chemistry 20100811 42
Innate immune recognition of flagellin is shared by transmembrane TLR5 and cytosolic Nlrc4 (NOD-like receptor family CARD (caspase activation recruitment domain) domain containing 4)/Naip5 (neuronal apoptosis inhibitory protein 5). TLR5 activates inflammatory genes through MYD88 pathway, whereas Nlrc4 and Naip5 assemble multiprotein complexes called inflammasomes, culminating in caspase-1 activation, IL-1β/IL-18 secretion, and pyroptosis. Although both TLR5 and Naip5/Nlrc4 pathways cooperate to ...[more]