Ontology highlight
ABSTRACT:
SUBMITTER: Zhao N
PROVIDER: S-EPMC2952215 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100803 42
ZIP14 is a transmembrane metal ion transporter that is abundantly expressed in the liver, heart, and pancreas. Previous studies of HEK 293 cells and the hepatocyte cell lines AML12 and HepG2 established that ZIP14 mediates the uptake of non-transferrin-bound iron, a form of iron that appears in the plasma during pathologic iron overload. In this study we investigated the role of ZIP14 in the cellular assimilation of iron from transferrin, the circulating plasma protein that normally delivers iro ...[more]