Ontology highlight
ABSTRACT:
SUBMITTER: Meyer-Hoffert U
PROVIDER: S-EPMC2952218 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Meyer-Hoffert Ulf U Wu Zhihong Z Kantyka Tomasz T Fischer Jan J Latendorf Ties T Hansmann Britta B Bartels Joachim J He Yinghong Y Gläser Regine R Schröder Jens-Michael JM
The Journal of biological chemistry 20100728 42
Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are tightly controlled by specific inhibitors, including the lymphoepithelial Kazal-type inhibitor (LEKTI) encoded by SPINK5 and LEKTI-2 encoded by SPINK9. Herein, we identify SPINK6 as a selective inhibitor of KLKs in the skin. Unlike LEKTI but similar to LEKTI-2, SPINK6 possesses only one typical Kazal domain. Its mRNA was detected to be expressed at low levels in several tissues and was induced during keratino ...[more]