Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC2952225 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Yang Hailing H Ganguly Anutosh A Cabral Fernando F
The Journal of biological chemistry 20100809 42
Drugs that target microtubules are thought to inhibit cell division and cell migration by suppressing dynamic instability, a "search and capture" behavior that allows microtubules to probe their environment. Here, we report that subtoxic drug concentrations are sufficient to inhibit plus-end microtubule dynamic instability and cell migration without affecting cell division or microtubule assembly. The higher drug concentrations needed to inhibit cell division act through a novel mechanism that g ...[more]