Ontology highlight
ABSTRACT:
SUBMITTER: Engle KM
PROVIDER: S-EPMC2952432 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Engle Keary M KM Wang Dong-Hui DH Yu Jin-Quan JQ
Journal of the American Chemical Society 20101001 40
Initial rate studies have revealed dramatic acceleration in aerobic Pd(II)-catalyzed C-H olefination reactions of phenylacetic acids when mono-N-protected amino acids are used as ligands. In light of these findings, systematic ligand tuning was undertaken, which has resulted in drastic improvements in substrate scope, reaction rate, and catalyst turnover. We present evidence from intermolecular competition studies and kinetic isotope effect experiments that implies that the observed rate increas ...[more]