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Serological evidence of human klassevirus infection.

ABSTRACT: Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.

SUBMITTER: Greninger AL 

PROVIDER: S-EPMC2952992 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Serological evidence of human klassevirus infection.

Greninger Alexander L AL   Holtz Lori L   Kang Gagandeep G   Ganem Donald D   Wang David D   DeRisi Joseph L JL  

Clinical and vaccine immunology : CVI 20100825 10

Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an a  ...[more]

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