Serological evidence of human klassevirus infection.
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ABSTRACT:
SUBMITTER: Greninger AL
PROVIDER: S-EPMC2952992 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Serological evidence of human klassevirus infection.
Greninger Alexander L AL Holtz Lori L Kang Gagandeep G Ganem Donald D Wang David D DeRisi Joseph L JL
Clinical and vaccine immunology : CVI 20100825 10
Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an a ...[more]
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