Ontology highlight
ABSTRACT:
SUBMITTER: Escobar-Alvarez S
PROVIDER: S-EPMC2953058 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Escobar-Alvarez Sindy S Gardner Jeffrey J Sheth Aneesh A Manfredi Giovanni G Yang Guangli G Ouerfelli Ouathek O Heaney Mark L ML Scheinberg David A DA
Molecular and cellular biology 20100830 21
Deformylases are metalloproteases in bacteria, plants, and humans that remove the N-formyl-methionine off peptides in vitro. The human homolog of peptide deformylase (HsPDF) resides in the mitochondria, along with its putative formylated substrates; however, the cellular function of HsPDF remains elusive. Here we report on the function of HsPDF in mitochondrial translation and oxidative phosphorylation complex biogenesis. Functional HsPDF appears to be necessary for the accumulation of mitochond ...[more]