Ontology highlight
ABSTRACT:
SUBMITTER: Moussa O
PROVIDER: S-EPMC2953061 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Moussa Omar O LaRue Amanda C AC Abangan Romeo S RS Williams Christopher R CR Zhang Xian K XK Masuya Masahiro M Gong Yong Z YZ Spyropoulos Demetri D DD Ogawa Makio M Gilkeson Gary G Watson Dennis K DK
Molecular and cellular biology 20100907 21
Targeted disruption of the Fli1 gene results in embryonic lethality. To dissect the roles of functional domains in Fli1, we recently generated mutant Fli1 mice that express a truncated Fli1 protein (Fli1(ΔCTA)) that lacks the carboxy-terminal regulatory (CTA) domain. Heterozygous Fli1(ΔCTA) mice are viable, while homozygous mice have reduced viability. Early postnatal lethality accounts for 30% survival of homozygotes to adulthood. The peripheral blood of these viable Fli1(ΔCTA)/Fli1(ΔCTA) homoz ...[more]