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Intragenic recombination as a mechanism of genetic diversity in bluetongue virus.


ABSTRACT: Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unknown whether intragenic recombination can occur and contribute to the process in the virus. We present here several BTV groups containing mosaic genes to reveal that intragenic recombination can take place between the virus strains and play a potential role in bringing novel BTV lineages.

SUBMITTER: He CQ 

PROVIDER: S-EPMC2953192 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Intragenic recombination as a mechanism of genetic diversity in bluetongue virus.

He Cheng-Qiang CQ   Ding Nai-Zheng NZ   He Mei M   Li Shan-Ni SN   Wang Xing-Ming XM   He Hong-Bin HB   Liu Xin-Fa XF   Guo Hong-Shan HS  

Journal of virology 20100811 21


Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unkno  ...[more]

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