Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise.

ABSTRACT:

Background

Muscle regeneration depends on satellite cells, myogenic stem cells that reside on the myofiber surface. Reduced numbers and/or decreased myogenic aptitude of these cells may impede proper maintenance and contribute to the age-associated decline in muscle mass and repair capacity. Endurance exercise was shown to improve muscle performance; however, the direct impact on satellite cells in aging was not yet thoroughly determined. Here, we focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. Young and old rats of both genders underwent 13 weeks of treadmill-running or remained sedentary.

Methodology

Gastrocnemius muscles were assessed for the effect of age, gender and

SUBMITTER: Shefer G 

PROVIDER: S-EPMC2953499 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature