Ontology highlight
ABSTRACT:
SUBMITTER: Grespi F
PROVIDER: S-EPMC2953534 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cell death and differentiation 20100813 11
Tight transcriptional regulation, alternative splicing and/or post-translational modifications of BH3-only proteins fine-tune their proapoptotic function. In this study, we characterize the gene locus of the BH3-only protein Bmf (Bcl-2-modifying factor) and describe the generation of two major isoforms from a common transcript in which initiation of protein synthesis involves leucine-coding CUG. Bmf(CUG) and the originally described isoform, Bmf-short, display comparable binding affinities to pr ...[more]