Synthetic associations in the context of genome-wide association scan signals.
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ABSTRACT:
SUBMITTER: Orozco G
PROVIDER: S-EPMC2953742 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Synthetic associations in the context of genome-wide association scan signals.
Orozco Gisela G Barrett Jeffrey C JC Zeggini Eleftheria E
Human molecular genetics 20100830 R2
Genome-wide association studies (GWAS) have successfully identified a large number of genetic variants associated with complex traits, but these only explain a small proportion of the total heritability. It has been recently proposed that rare variants can create 'synthetic association' signals in GWAS, by occurring more often in association with one of the alleles of a common tag single nucleotide polymorphism. While the ultimate evaluation of this hypothesis will require the completion of larg ...[more]
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