Ontology highlight
ABSTRACT:
SUBMITTER: Zheng YL
PROVIDER: S-EPMC2954124 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Zheng Ya-Li YL Li Bing-Sheng BS Rudrabhatla Parvathi P Shukla Varsha V Amin Niranjana D ND Maric Dragan D Kesavapany Sashi S Kanungo Jyotshnabala J Pareek Tej K TK Takahashi Satoru S Grant Philip P Kulkarni Ashok B AB Pant Harish C HC
Molecular biology of the cell 20100901 20
Cyclin-dependent kinase 5 (Cdk5) plays a key role in the development of the mammalian nervous system; it phosphorylates a number of targeted proteins involved in neuronal migration during development to synaptic activity in the mature nervous system. Its role in the initial stages of neuronal commitment and differentiation of neural stem cells (NSCs), however, is poorly understood. In this study, we show that Cdk5 phosphorylation of p27(Kip1) at Thr187 is crucial to neural differentiation becaus ...[more]