Dataset Information

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

ABSTRACT: Consumption of flavonoid-containing foods may be useful for the management of hypertension.We investigated whether 100% Concord grape juice lowers blood pressure in patients with prehypertension and stage 1 hypertension.We conducted a double-blind crossover study to compare the effects of grape juice (7 mL · kg?¹ · d?¹) and matched placebo beverage on 24-h ambulatory blood pressure, stress-induced changes in blood pressure, and biochemical profile. Participants consumed each beverage for 8 wk with a 4-wk rest period between beverages. They ceased consumption of grapes and other flavonoid-containing beverages throughout the study.We enrolled 64 otherwise healthy patients taking no antihypertensive medications (31% women, 42% black, age 43 ± 12 y). Baseline mean (± SD) cuff blood pressure was 138 ± 7 (systolic)/82 ± 7 (diastolic) mm Hg. No effects on the primary endpoint of 24-h mean systolic blood pressure, diastolic blood pressure, or stress-induced changes in blood pressure were observed. A secondary endpoint was nocturnal dip in systolic pressure. At baseline, nocturnal pressure was 8.3 ± 7.1% lower at night than during daytime. The mean nocturnal dip increased 1.4 percentage points after grape juice and decreased 2.3 percentage points after placebo (P = 0.005). Fasting blood glucose was 91 ± 10 mg/dL at baseline for the entire cohort. Glucose decreased 2 mg/dL after consumption of grape juice and increased 1 mg/dL after consuming the placebo (P = 0.03).We observed no effect of grape juice on ambulatory blood pressure in this cohort of relatively healthy individuals with modestly elevated blood pressure. Secondary analyses suggested favorable effects on nocturnal dip and glucose homeostasis that may merit further investigation. This trial was registered at clinicaltrials.gov as NCT00302809.

SUBMITTER: Dohadwala MM

PROVIDER: S-EPMC2954442 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

Dohadwala Mustali M MM Hamburg Naomi M NM Holbrook Monika M Kim Brian H BH Duess Mai-Ann MA Levit Aaron A Titas Megan M Chung William B WB Vincent Felix B FB Caiano Tara L TL Frame Alissa A AA Keaney John F JF Vita Joseph A JA

The American journal of clinical nutrition 20100915 5

<h4>Background</h4>Consumption of flavonoid-containing foods may be useful for the management of hypertension.<h4>Objective</h4>We investigated whether 100% Concord grape juice lowers blood pressure in patients with prehypertension and stage 1 hypertension.<h4>Design</h4>We conducted a double-blind crossover study to compare the effects of grape juice (7 mL · kg⁻¹ · d⁻¹) and matched placebo beverage on 24-h ambulatory blood pressure, stress-induced changes in blood pressure, and biochemical prof ...[more]

PMID: 20844075

Similar Datasets

Project description:Background Nonpharmacologic interventions that modify lifestyle can lower blood pressure (BP) and have been assessed in numerous randomized controlled trials and pairwise meta-analyses. It is still unclear which intervention would be most efficacious. Methods and Results Bayesian network meta-analyses were performed to estimate the comparative effectiveness of different interventions for lowering BP. From 60 166 potentially relevant articles, 120 eligible articles (14 923 participants) with a median follow-up of 12 weeks, assessing 22 nonpharmacologic interventions, were included. According to the surface under the cumulative ranking probabilities and Grading of Recommendations Assessment, Development and Evaluation (GRADE) quality of evidence, for adults with prehypertension to established hypertension, high-quality evidence indicated that the Dietary Approach to Stop Hypertension (DASH) was superior to usual care and all other nonpharmacologic interventions in lowering systolic BP (weighted mean difference, 6.97 mm Hg; 95% credible interval, 4.50-9.47) and diastolic BP (weighted mean difference, 3.54 mm Hg; 95% credible interval, 1.80-5.28). Compared with usual care, moderate- to high-quality evidence indicated that aerobic exercise, isometric training, low-sodium and high-potassium salt, comprehensive lifestyle modification, breathing-control, and meditation could lower systolic BP and diastolic BP. For patients with hypertension, moderate- to high-quality evidence suggested that the interventions listed (except comprehensive lifestyle modification) were associated with greater systolic BP and diastolic BP reduction than usual care; salt restriction was also effective in lowering both systolic BP and diastolic BP. Among overweight and obese participants, low-calorie diet and low-calorie diet plus exercise could lower more BP than exercise. Conclusions DASH might be the most effective intervention in lowering BP for adults with prehypertension to established hypertension. Aerobic exercise, isometric training, low-sodium and high-potassium salt, comprehensive lifestyle modification, salt restriction, breathing-control, meditation and low-calorie diet also have obvious effects on BP reduction.

Dataset Information

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

Publications

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets