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The quest to understand heterotrimeric G protein signaling.

ABSTRACT: Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.

SUBMITTER: Tesmer JJ

PROVIDER: S-EPMC2954486 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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The quest to understand heterotrimeric G protein signaling.

Tesmer John J G JJ

Nature structural & molecular biology 20100601 6

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs. ...[more]

PMID: 20520658

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