Ontology highlight
ABSTRACT:
SUBMITTER: Smith MA
PROVIDER: S-EPMC2954498 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Developmental cell 20100901 3
To maintain mechanical homeostasis, cells must recognize and respond to changes in cytoskeletal integrity. By imaging live cells expressing fluorescently tagged cytoskeletal proteins, we observed that actin stress fibers undergo local, acute, force-induced elongation and thinning events that compromise their stress transmission function, followed by stress fiber repair that restores this capability. The LIM protein zyxin rapidly accumulates at sites of strain-induced stress fiber damage and is e ...[more]