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Host genetics and HIV-1: the final phase?

ABSTRACT: This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

SUBMITTER: Fellay J

PROVIDER: S-EPMC2954832 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Host genetics and HIV-1: the final phase?

Fellay Jacques J Shianna Kevin V KV Telenti Amalio A Goldstein David B DB

PLoS pathogens 20101014 10

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of th ...[more]

PMID: 20976252

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