Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC2955114 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Wu Yinghao Y Jin Xiangshu X Harrison Oliver O Shapiro Lawrence L Honig Barry H BH Ben-Shaul Avinoam A
Proceedings of the National Academy of Sciences of the United States of America 20100927 41
Intercellullar junctions formed by cadherins, including desmosomes and adherens junctions, comprise two dimensional arrays of "trans" dimers formed between monomers emanating from opposing cell surfaces. Lateral "cis" interfaces between cadherins from the same cell surface have been proposed to play a role in cadherin clustering. Although the molecular details of cis interactions remain uncertain, they must define an anisotropic arrangement where binding is favorable only in certain orientations ...[more]