Ontology highlight
ABSTRACT:
SUBMITTER: Jung H
PROVIDER: S-EPMC2955411 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Jung Heekyung H Lacombe Julie J Mazzoni Esteban O EO Liem Karel F KF Grinstein Jonathan J Mahony Shaun S Mukhopadhyay Debnath D Gifford David K DK Young Richard A RA Anderson Kathryn V KV Wichterle Hynek H Dasen Jeremy S JS
Neuron 20100901 5
In the developing spinal cord, regional and combinatorial activities of Hox transcription factors are critical in controlling motor neuron fates along the rostrocaudal axis, exemplified by the precise pattern of limb innervation by more than fifty Hox-dependent motor pools. The mechanisms by which motor neuron diversity is constrained to limb levels are, however, not well understood. We show that a single Hox gene, Hoxc9, has an essential role in organizing the motor system through global repres ...[more]