Ontology highlight
ABSTRACT:
SUBMITTER: Kooperberg C
PROVIDER: S-EPMC2955421 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Genetic epidemiology 20080401 3
In this paper we investigate the power to identify gene x gene interactions in genome-wide association studies. In our analysis we focus on two-stage analyses: analyses in which we only test for interactions between single nucleotide polymorphisms that show some marginal effect. We give two algorithms to compute significance levels for such an analyses. One involves a Bonferoni correction on the number of interactions that are actually tested, and one is a resampling procedure similar to the one ...[more]