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Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.

ABSTRACT: The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.

SUBMITTER: Geraldes A

PROVIDER: S-EPMC2955732 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.

Geraldes Armando A Rambo Teri T Wing Rod A RA Ferrand Nuno N Nachman Michael W MW

Molecular biology and evolution 20100604 11

The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have rem ...[more]

PMID: 20525900

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