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Describing the mechanism of antimicrobial peptide action with the interfacial activity model.

ABSTRACT: Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular understanding of their mechanism of action is still lacking. Here we summarize current knowledge for both synthetic vesicle experiments and microbe experiments, with a focus on comparisons between the two. Microbial experiments are done at peptide to lipid ratios that are at least 4 orders of magnitude higher than vesicle-based experiments. To close the gap between the two concentration regimes, we propose an "interfacial activity model", which is based on an experimentally testable molecular image of AMP-membrane interactions. The interfacial activity model may be useful in driving engineering and design of novel AMPs.

SUBMITTER: Wimley WC

PROVIDER: S-EPMC2955829 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Describing the mechanism of antimicrobial peptide action with the interfacial activity model.

Wimley William C WC

ACS chemical biology 20101001 10

Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular understanding of their mechanism of action is still lacking. Here we summarize current knowledge for both synthetic vesicle experiments and microbe experiments, with a focus on comparisons between the two. Microbial experiments are done at peptide to lipid ratios that are at least 4 orders of magnitude higher than vesicle-based experiments. To close the gap between the two concentration regimes, we propose an ...[more]

PMID: 20698568

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