Ontology highlight
ABSTRACT:
SUBMITTER: Malin S
PROVIDER: S-EPMC2956121 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Malin Stephen S McManus Shane S Cobaleda César C Novatchkova Maria M Delogu Alessio A Bouillet Philippe P Strasser Andreas A Busslinger Meinrad M
Nature immunology 20091129 2
STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus. Using conditional mutagenesis to delete the gene encoding the transcription factor STAT5, we demonstrate that the development of pro-B cells was restored by transgenic expression of the prosurvival protein Bcl-2, which compensated for loss of the antiapoptotic protei ...[more]