Differential expression and network inferences through functional data modeling.
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ABSTRACT:
SUBMITTER: Telesca D
PROVIDER: S-EPMC2956129 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Differential expression and network inferences through functional data modeling.
Telesca Donatello D Inoue Lurdes Y T LY Neira Mauricio M Etzioni Ruth R Gleave Martin M Nelson Colleen C
Biometrics 20081113 3
Time course microarray data consist of mRNA expression from a common set of genes collected at different time points. Such data are thought to reflect underlying biological processes developing over time. In this article, we propose a model that allows us to examine differential expression and gene network relationships using time course microarray data. We model each gene-expression profile as a random functional transformation of the scale, amplitude, and phase of a common curve. Inferences ab ...[more]
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