Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Q
PROVIDER: S-EPMC2956131 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20100801 16
Daidzein (1) is a natural estrogenic isoflavone. We report here that 1 can be transformed into anti-estrogenic ligands by simple alkyl substitutions of the 7-hydroxyl hydrogen. To test the effect of such structural modifications on the hormonal activities of the resulting compounds, a series of daidzein analogues have been designed and synthesized. When MCF-7 cells were treated with the analogues, those resulting from hydrogen substitution by isopropyl (3d), isobutyl (3f), cyclopentyl (3g), and ...[more]