Ontology highlight
ABSTRACT:
SUBMITTER: Huarte M
PROVIDER: S-EPMC2956184 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Cell 20100801 3
Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally represse ...[more]