Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2956582 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Li Xiaokai X Liu Nina N Zhang Huaning H Knudson Susan E SE Slayden Richard A RA Tonge Peter J PJ
Bioorganic & medicinal chemistry letters 20100821 21
Menaquinone is an essential component of the electron transport chain in many pathogens and consequently enzymes in the menaquinone biosynthesis pathway are potential drug targets for the development of novel antibacterial agents. In order to identify leads that target MenB, the 1,4-dihydroxy-2-naphthoyl-CoA synthase from Mycobacterium tuberculosis, a high-throughput screen was performed. Several 1,4-benzoxazines were identified in this screen and subsequent SAR studies resulted in the discovery ...[more]