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Paramyxovirus disruption of interferon signal transduction: STATus report.

ABSTRACT: RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.

SUBMITTER: Ramachandran A

PROVIDER: S-EPMC2956620 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Paramyxovirus disruption of interferon signal transduction: STATus report.

Ramachandran Aparna A Horvath Curt M CM

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20090901 9

RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means o ...[more]

PMID: 19694544

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