Ontology highlight
ABSTRACT:
SUBMITTER: Sharp TM
PROVIDER: S-EPMC2956632 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Sharp Tyler M TM Guix Susana S Katayama Kazuhiko K Crawford Sue E SE Estes Mary K MK
PloS one 20101018 10
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the Golgi. Norwalk virus nonstructural protein p22 contains a YXΦESDG motif that mimics a di-acidic ER export signal in both sequence and function. However, unlike normal ER export signals, the ER export signal mimic of p22 is necessary for apparent inh ...[more]