Dataset Information

Routine HIV screening in France: clinical impact and cost-effectiveness.

ABSTRACT:

Background

In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in both the epidemiology of infection and HIV testing behaviors warrant a setting-specific analysis for France.

Methods/principal findings

We estimated the life expectancy (LE), cost and cost-effectiveness of alternative HIV screening strategies in the French general population and high-risk sub-populations using a computer model of HIV detection and treatment, coupled with French national clinical and economic data. We compared risk-factor-based HIV testing ("current practice") to universal routine, voluntary HIV screening in adults aged 18-69. Screening frequencies ranged from once to annually. Input data included mean age (42 years), undiagnosed HIV prevalence (0.10%), annual HIV incidence (0.01%), test acceptance (79%), linkage to care (75%) and cost/test (€43). We performed sensitivity analyses on HIV prevalence and incidence, cost estimates, and the transmission benefits of ART. "Current practice" produced LEs of 242.82 quality-adjusted life months (QALM) among HIV-infected persons and 268.77 QALM in the general population. Adding a one-time HIV screen increased LE by 0.01 QALM in the general population and increased costs by €50/person, for a cost-effectiveness ratio (CER) of €57,400 per quality-adjusted life year (QALY). More frequent screening in the general population increased survival, costs and CERs. Among injection drug users (prevalence 6.17%; incidence 0.17%/year) and in French Guyana (prevalence 0.41%; incidence 0.35%/year), annual screening compared to every five years produced CERs of €51,200 and €46,500/QALY.

Conclusions/significance

One-time routine HIV screening in France improves survival compared to "current practice" and compares favorably to other screening interventions recommended in Western Europe. In higher-risk groups, more frequent screening is economically justifiable.

SUBMITTER: Yazdanpanah Y

PROVIDER: S-EPMC2956760 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Publications

Routine HIV screening in France: clinical impact and cost-effectiveness.

Yazdanpanah Yazdan Y Sloan Caroline E CE Charlois-Ou Cécile C Le Vu Stéphane S Semaille Caroline C Costagliola Dominique D Pillonel Josiane J Poullié Anne-Isabelle AI Scemama Olivier O Deuffic-Burban Sylvie S Losina Elena E Walensky Rochelle P RP Freedberg Kenneth A KA Paltiel A David AD

PloS one 20101001 10

<h4>Background</h4>In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in both the epidemiology of infection and HIV testing behaviors warrant a setting-specific analysis for France.<h4>Methods/principal findings</h4>We estimated the life expectancy (LE), cost and cost-effectiveness of alternative HIV screening strategies in the French general ...[more]

PMID: 20976112

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Dataset Information

Routine HIV screening in France: clinical impact and cost-effectiveness.

Background

Methods/principal findings

Conclusions/significance

Publications

Routine HIV screening in France: clinical impact and cost-effectiveness.

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