Ontology highlight
ABSTRACT:
SUBMITTER: Gardner LA
PROVIDER: S-EPMC2956792 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Gardner Lidia A LA Hajjhussein Hassan H Frederick-Dyer Katherine C KC Bahouth Suleiman W SW
Cellular signalling 20100818 1
ß1-adrenergic receptors (ß1-AR) are internalized in response to agonists and then recycle back for another round of signaling. The serine 312 to alanine mutant of the ß1-AR (S312A) is internalized but does not recycle. We determined that WT ß1-AR and S312A were internalized initially to an early sorting compartment because they colocalized by >70% with the early endosomal markers rab5a and early endosomal antigen-1 (EEA1). Subsequently, the WT ß1-AR trafficked via rab4a-expressing sorting endoso ...[more]