Ontology highlight
ABSTRACT:
SUBMITTER: Shi X
PROVIDER: S-EPMC2956987 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Shi Xiaoyan X Cao Shanjin S Mitsuhashi Maki M Xiang Zhaoying Z Ma Xiaojing X
Journal of immunology (Baltimore, Md. : 1950) 20040401 7
IL-12 is a major activator of tumor-killing NK cells and CTL. IFN-gamma mediates most of the well-known immunological activities of IL-12. In this study, we report IFN-gamma-independent activities induced by therapeutic application of rIL-12 in restricting tumor growth and metastasis in the 4T1 murine mammary carcinoma model. IFN-gamma-deficient mice carrying 4T1 tumor exhibit no gross defect in the number of tumor-infiltrating lymphocytes but have exaggerated angiogenesis in the tumor. Administ ...[more]