Ontology highlight
ABSTRACT:
SUBMITTER: Lin HJ
PROVIDER: S-EPMC2957151 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Lin Hung-Jen HJ Tseng Ching-Ping CP Lin Chia-Fan CF Liao Mei-Huei MH Chen Chuan-Mu CM Kao Shung-Te ST Cheng Ju-Chien JC
Evidence-based complementary and alternative medicine : eCAM 20100926
The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages ...[more]