Ontology highlight
ABSTRACT:
SUBMITTER: Appenzeller-Herzog C
PROVIDER: S-EPMC2957208 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Appenzeller-Herzog Christian C Riemer Jan J Zito Ester E Chin King-Tung KT Ron David D Spiess Martin M Ellgaard Lars L
The EMBO journal 20100827 19
The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds. Both the oxidase Ero1α and the oxidoreductase protein disulphide isomerase (PDI) strongly contribute to the rapid recovery kinetics, but experiments in ERO1-deficient cells indicate the existence of parallel pathways for disulphide generation. We f ...[more]