NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.
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ABSTRACT:
SUBMITTER: Yang JQ
PROVIDER: S-EPMC2957215 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.
Yang Jun-Qi JQ Liu Hongzhu H Diaz-Meco Maria T MT Moscat Jorge J
The EMBO journal 20100831 19
Allergic airway inflammation is a disease in which T helper 2 (Th2) cells have a critical function. The molecular mechanisms controlling Th2 differentiation and function are of paramount importance in biology and immunology. Recently, a network of PB1-containing adapters and kinases has been shown to be essential in this process owing to its function in regulating cell polarity and the activation of critical transcription factors. Here, we show in vivo data showing that T-cell-specific NBR1-defi ...[more]
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