Ontology highlight
ABSTRACT:
SUBMITTER: Stoller DA
PROVIDER: S-EPMC2957346 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Stoller Douglas A DA Fahrenbach John P JP Chalupsky Karel K Tan Bi-Hua BH Aggarwal Nitin N Metcalfe Jamie J Hadhazy Michele M Shi Nian-Qing NQ Makielski Jonathan C JC McNally Elizabeth M EM
American journal of physiology. Heart and circulatory physiology 20100723 4
Sulfonylurea receptor-containing ATP-sensitive potassium (K(ATP)) channels have been implicated in cardioprotection, but the cell type and constitution of channels responsible for this protection have not been clear. Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) channels in cardiac, skeletal, and smooth muscle. As previously reported, SUR2 null mice develop e ...[more]