Ontology highlight
ABSTRACT:
SUBMITTER: El-Ayache NC
PROVIDER: S-EPMC2957478 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
El-Ayache Nadine C NC Li Shih-Hon SH Warnock Mark M Lawrence Daniel A DA Emal Cory D CD
Bioorganic & medicinal chemistry letters 20091221 3
Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series of compounds based on bis-arylsulfonamide and aryl sulfonimide motifs that show potent and specific activity towards PAI-1. Inhibitors containing short linking units between the sulfonyl moieties and a 3,4-dihydroxy aryl substitution pattern sh ...[more]